Overview
Work History
Education
Skills
Awards & Grants
Abstracts
Publications
Community Service
Projects
Languages
Mailingaddress
Timeline
Generic

Feyza Gul Ozbay Kurt

Heidelberg

Overview

10
10
years of professional experience

Work History

Postdoctoral Researcher

German Cancer Research Center
10.2023 - Current

Project: Quantifying systemic immunosuppression to personalize cancer therapy (SERPENTINE)

PhD student

German Cancer Research Center
10.2020 - 09.2023

Project: Targeting MDSC-mediated immunosuppression in melanoma

Researcher

Hacettepe University
09.2019 - 08.2020
  • Investigating the role of PMN-MDSC in the tumor microenvironment of lung cancer.

Summer Internship

Ankara University Cancer Institute
05.2016 - 07.2016
  • Investigating the effect of low dose chemotherapy on angiogenesis in colon cancer patients.

Summer Internship

Zentrum Für Molekular Neurobiologie
06.2014 - 08.2014
  • Investigating Ret signaling and the neurotrophic factor GDNF in Parkinson's disease.

Education

Ph.D. - Faculty of Biosciences

Heidelberg University
Heidelberg, Germany
09.2023

Master of Science - Department of Basic Oncology, Tumor Biology and Immunology

Hacettepe University
Ankara, Turkey
08.2019

Bachelor of Science - Molecular Biology and Genetics

Bilkent University
Ankara, Turkey
01.2017

Skills

    Laboratory Techniques:

  • Conventional and spectral multi-color Flow Cytometry
  • Single cell RNA sequencing library preparation
  • ELISA, Luminex
  • Fluorescent-activated cell sorting (FACS) and magnetic-activated cell sorting (MACS)
  • Human Blood Handling: Peripheral blood mononuclear cells (PBMCs), Polymorphonuclear cells (PMNs)
  • Cell Culture: Isolation and culturing of cancer cell lines, primary human blood cells (monocytes, neutrophils, lymphocytes, NK cells)
  • Functional assays with primary cells: Suppression of T cell proliferation assays, killing assays
  • Molecular Biology techniques: Western Blotting, RNA isolation, Primer design, Gel Electrophoresis, RT-PCR
  • Multiplexed imaging: MACSima imaging cyclic staining (MICS)
  • Cytotoxicity Testing (MTT assay)
  • Scientific Writing and Project Management:

  • Developed and executed experimental designs
  • Managed a number of research projects from conception to completion
  • Computational Skills:

  • Basic knowledge of R programming language for data analysis and visualization
  • Proficient in FlowJo and Cytobank for advanced analysis of flow cytometry data, including gating, population characterization, and visualization

Awards & Grants

  • Graduate School Scholarship Programme (GSSP), German Academic Exchange Service (DAAD), 10/2020, 10/2023
  • International Molecular Immunology and Immunogenetics Congress (MIMIC IV) Travel Grant, Bursa, Turkey, 04/27/2019, 04/29/2019
  • European Cooperation in Science and Technology (COST) Travel Grant, COST Action [BM1404] event: 6th MC/WG Meeting and ECI Workshop/Conference; 1st European Conference on Myeloid Regulatory Cells, Essen, Germany, 11/01/2018, 11/03/2018
  • The European Federation of Immunological Societies (EFIS) Travel Grant, 5th European Congress of Immunology (ECI 2018), Amsterdam, Netherlands, 09/02/2018, 09/05/2018

Abstracts

  • Feyza Gul Ozbay Kurt, Beatrice Ana Cicortas, Rebekka Bitsch, Jochen Utikal, Viktor Umansky, S100A9 and HMGB1 regulates the immunosuppression by MDSC in melanoma, 24-27 April 2023, Oral Presentation
  • Feyza Gul Ozbay Kurt, Rebekka Weber, Jochen Utikal, Viktor Umansky, The role of TLR4 signaling in myeloid cell mediated immune suppression in melanoma, Hallmarks of Skin Cancer Conference, 29 November 2021, Poster Presentation
  • Feyza Gul Ozbay Kurt, Rebekka Weber, Jochen Utikal, Viktor Umansky, The role of TLR4 signaling in myeloid cell mediated immune suppression in melanoma, 18TH CIMT Annual Meeting, 10-12 May 2021, eTalk
  • Feyza Gul Ozbay, Gunes Esendagli, Evaluation of T cell responses in the co-cultures established with neutrophils, monocytes, and lung adenocarcinoma cells, Onkolojide Iz Birakanlar Zirvesi, Antalya, Turkey, 14-16 November 2019, Oral Presentation
  • Pinar Acar-Ozen, Asli Tuncer, Didem Ozkazanc, Feyza Gul Ozbay, Beren Karaosmanoglu, Sibel Goksen, Ekim Taskiran, Gunes Esendagli, Rana Karabudak, Transcriptomic and immunophenotypic analyses on natural killer cells in RRMS patients under fingolimod therapy, 35th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), Stockholm, Sweden, 11-13 September 2019, Poster Presentation
  • Stephan Winklmeier, Miriam Schluter, Melania Spadaro, Franziska S. Thaler, Atay Vural1,, Ramona Gerhards, Caterina Macrini, Asli Kurne3, Berin Inan, Gunes Esendagli, Feyza Gul Ozbay, Reinhard Hohlfeld, Tania Kumpfel, Edgar Meinl, Circulating myelin oligodendrocyte glycoprotein (MOG)-specific B cells stratify patients with MOG-antibodies, II Joint Meeting of the German Society for Immunology (DGfl) and the Italian Society of Immunology, Munich, Germany, 10-13 September 2019, Poster Presentation
  • Feyza Gul Ozbay, Gunes Esendagli, Neutrophils reinforce cytotoxic T cell responses in a co-culture model mimicking tumor microenvironment in lung cancer, International Molecular Immunology and Immunogenetics Congress (MIMIC IV), Bursa, Turkey, 27-29 April 2019, Poster Presentation
  • Feyza Gul Ozbay, Gunes Esendagli, Evaluation of cytotoxic T cell responses in a co-culture model employing neutrophils, monocytes, and lung cancer cells, 1st European Symposium on Myeloid Regulatory Cells in Health and Disease (ESMRC), Essen, Germany, 1-3 November 2018, Poster Presentation
  • Feyza Gul Ozbay, Gunes Esendagli, Evaluation of helper T cell proliferation in the co-cultures of lung adenocarcinoma cells, neutrophils, and monocytes, European Congress of Immunology (ECI 2018), Amsterdam, Netherlands, 2-5 September 2018, Poster Presentation

Publications

  • Lasser S.; Özbay Kurt, F.G.; Arkhypov I.; Utikal J.; Umansky V., Myeloid-derived suppressor cells in cancer and cancer therapy, Nat Rev Clin Oncol, 2024, 21, 2, 147-164, 10.1038/s41571-023-00846-y
  • Lepper A.; Bitsch R.; Özbay Kurt, F.G.; Arkhypov I.; Lasser S.; Utikal J.; Umansky V., Melanoma patients with immune-related adverse events after immune checkpoint inhibitors are characterized by a distinct immunological phenotype of circulating T cells and M-MDSCs, Oncoimmunology, 2023, 12, 1, 2247303
  • Zbay Kurt, F.G.; Lasser S.; Arkhypov I.; Utikal J.; Umansky V., Enhancing immunotherapy response in melanoma: myeloid-derived suppressor cells as a therapeutic target, J Clin Invest, 2023, 133, 13, e170762
  • Zbay Kurt, F.G.; Lepper, A.; Gerhards, C.; Roemer, M.; Lasser, S.; Arkhypov, I.; Bitsch, R.; Bugert, P.; Altevogt, P.; Gouttefangeas,C.; Neumaier M.; Utikal J.; Umansky V., Booster dose of mRNA vaccine augments waning T cell and antibody responses against SARS-CoV-2, Front Immunol, 2022, 13, 1012526
  • Arkhypov, I.,Ozbay Kurt, F.G, Bitsch, R.; Novak, D.; Petrova, V.; Lasser, S.; Hielscher, T.; Groth, C.; Lepper, A.; Hu, X; Li, Wi; Utikal, J; Altevogt P; Umansky, V., HSP90alpha induces immunosuppressive myeloid cells in melanoma via TLR4 signaling, J Immunother Cancer, 2022, 10, e005551
  • Bitsch R, Kurzay A, Ozbay Kurt F, De La Torre C, Lasser S, Lepper A, Siebenmorgen A, Muller V, Altevogt P, Utikal J, Umansky V., STAT3 inhibitor napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice, J Immunother Cancer, 2022
  • Christopher Groth, Rebekka Weber, Samantha Lasser, Feyza Gül Özbay, Annina Kurzay, Vera Petrova, Peter Altevogt, Jochen Utikal, Viktor Umansky, Tumor promoting capacity of polymorphonuclear myeloid-derived suppressor cells and their neutralization, International Journal of Cancer, 2021, July, 10.1002/ijc.33731
  • M. Alper Kursunel, Ekim Z. Taskiran, Ece Tavukcuoglu, Hamdullah Yanik, Funda Demirag, Beren Karaosmanoglu, Feyza Gul Ozbay, Aysegul Uner, Dorina Esendagli, Derya Kizilgoz, Ulku Yilmaz, Gunes Esendagli, Cancer Immunology, Immunotherapy, 2021, July, 10.1007/s00262-021-02998-1
  • Nazire Pinar Acar, Asli Tuncer, Didem Ozkazanc, Feyza Gul Ozbay, Beren Karaosmanoglu, Sibel Goksen, Ekim Taskiran, Gunes Esendagli, Rana Karabudak, An immunological and transcriptomics approach on differential modulation of NK cells in multiple sclerosis patients under interferon-β1 and fingolimod therapy, Journal of Neuroimmunology, 2020, July, 347, 577353, 10.1016/j.jneuroim.2020.577353
  • Sayiner O., Arisoy S., Comoglu T., Ozbay F.G., Esendagli G., Development and in vitro evaluation for temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme, Journal of Drug Delivery Science and Technology, 2020, February, 57, 101627, 10.1016/j.jddst.2020.101627
  • Winklmeier S., Schluter M.,Spadora M, Thaler F.S, Vural A., Gerhards R., Macrini C., Mader S., Kurne A., Inan B., Karabudak R., Ozbay F.G., Esendagli G., Hohfeld R., Kumpfel T., Meinl E., Identification of circulating MOG-specific B cells in patients with MOG-antibodies, Neurol Neuroimmunol Neuroinflamm, 2019, October, 6, 5, e625

Community Service

  • The Project of Leonardo Da Vinci, Bucharest, Romania, May 2012, Providing career skills for students with disabilities
  • Comenius Project, Manchester, England, May 2009, Focused on environmental pollution and recycling

Projects

  • Quantifying systemic immunosuppression to personalize cancer therapy (SERPENTINE), Researcher, 2020, today
  • Targeting MDSC-mediated immunosuppression in melanoma, Researcher, 2020-2024.
  • Transcriptomic profiling of MDSC from melanoma patients in combination with an in vitro suppression of T cell proliferation assay, Researcher, 2020-2021
  • Evaluation of T cell responses in the co-cultures of lung adenocarcinoma cells, neutrophils, and monocytes, Researcher, 2017-2020
  • Hacettepe University Scientific Research Projects Coordination Unit Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme, Researcher, 2019-2020
  • Transcriptomic and immunophenotypic analyses on natural killer cells in multiple sclerosis patients under fingolimod therapy, Researcher, 2018-2019
  • Circulating myelin oligodendrocyte glycoprotein (MOG)-specific B cells stratify patients with MOG-antibodies, Researcher, 2018-2019

Languages

Turkish
Bilingual or Proficient (C2)
English
Bilingual or Proficient (C2)
German
Intermediate (B1)

Mailingaddress

Merianstr. 1, 69117, Heidelberg, Germany

Timeline

Postdoctoral Researcher

German Cancer Research Center
10.2023 - Current

PhD student

German Cancer Research Center
10.2020 - 09.2023

Researcher

Hacettepe University
09.2019 - 08.2020

Summer Internship

Ankara University Cancer Institute
05.2016 - 07.2016

Summer Internship

Zentrum Für Molekular Neurobiologie
06.2014 - 08.2014

Ph.D. - Faculty of Biosciences

Heidelberg University

Master of Science - Department of Basic Oncology, Tumor Biology and Immunology

Hacettepe University

Bachelor of Science - Molecular Biology and Genetics

Bilkent University
Feyza Gul Ozbay Kurt