Julio D. Perez

Molecular neuroscientist specializing in single-cell and subcellular transcriptomics. I develop and apply cutting-edge single-cell subcellular methods to uncover principles of gene regulation within the cell. My goal as an independent group leader is to establish a genomics research program that bridges cell biology and systems genomics, advancing our understanding of how molecular subcellular organization underpins cell identity and plasticity.

Best Poster Prize, Max Planck Institute for Brain Research Retreat, 2022, Best Poster Prize, Genomic Imprinting, Epigenetics and Physiology Functions Workshop, 2016, Molecules, Cells, and Organism Program Retreat Poster of the Year Award, 2014, Morris E. Zukerman Graduate Fellowship Fund for Exceptional Students in Brain Science, 2008-2015, Outstanding Research Award of the Ronald E. McNair Program at the Inter American University of Puerto Rico, 2007

• Perez, JD & Schuman, E. Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons. Bio-protocol, (2022).
• Perez, JD, Fusco, C. M. & Schuman, E. M. A Functional Dissection of the mRNA and Locally Synthesized Protein Population in Neuronal Dendrites and Axons. Annual Reviews of Genetics, (2021).
• Perez JD, et al. Subcellular sequencing of single neurons reveals the dendritic transcriptome of interneurons. eLife, (2021)
• Alvarez-Castelao B, tom Dieck S, Fusco CM, Donlin-Asp P, Perez JD (contributed RNA-seq analyses), Schuman EM. The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition. eLife, (2020)
• Moffitt JR, Bambah-Mukku D, Eichhorn SW, Vaughn E, Shekhar K, Perez JD (established scRNA-seq protocol), Rubinstein ND, Hao J, Regev A, Dulac C, Zhuang X. Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region. Science, (2018)
• Perez JD, Rubinstein ND, Dulac C. New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain. Annual Review of Neuroscience, (2016)
• Perez JD, et al. Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain. eLife (2015)
• Pérez-Andino J, Buck CB, Ribbeck K. Adsorption of human papillomavirus 16 to live human sperm. PLoS ONE, (2009)

• Supervised one postdoc, one PhD student, three technicians, three MSc students, and multiple interns during the postdoc.
• Supervised two BS students and multiple interns during PhD.
• Guest Lecture on “Frontiers of Interdisciplinary Science in Human Health and Disease” Undergraduate Course at Massachusetts Institute of Technology (MIT), 2024.
• Master class on Modern Techniques in Neuroscience, IMPRS PhD program for Neural circuits, Max Planck Institute for Brain Research, 2019.
• Teaching Fellow of Professor Catherine Dulac in the “Molecular Biology of Sensory Systems” Course at Harvard University, 2012.
• Teaching Assistant in the 1st Molecular Neuroanatomy Course of the Allen Institute for Brain Science at Okinawa Institute for Science and Technology (OIST), 2011.
• Teaching Assistant to Professors Jeff Lichtman and Josh Sanes in the “Neurobiology of Behavior” course at Harvard University, 2010.
• Teaching Assistant to Professors Daniel Kahn and Robert Lue in the “Life Sciences 1a” course at Harvard University, 2009.